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Matriderm & Elastin

Matriderm is the only dermal matrix that contains both collagen and elastin.

Matriderm is supplemented with solubilised Elastin by partial hydrolysis (a non-chemical, thermal bond) derived from the Bovine Nuchal ligament.

TEM image with negativ staining and immunogold labelling with Elastin Antibody, M. Mörgelin, Lund, Swed

 

Elastin provides reduced scar contraction and enhanced tissue elasticity

Elastin from Matriderm replaces the natural elastin found in skin and other tissues, providing the mechanical resilience and elasticity essential to the skin. It has been demonstrated that the elastin component improves the stability and elasticity of the regenerating tissue. The body reduces the production of elastin as you age.

“Dermal replacements containing hydrolysed elastin demonstrate improved properties over elastin-free properties in regard to wound contraction and tissue regeneration” (Rnjak, Wise et al 2011)
Papers also show improved skin elasticity with Matriderm (Ryssel, Gazyakan et al 2008) and that elastin provides support and proliferation of dermal fibroblasts in vitro (Annabi, Mithiux et al 2009)

Clinical studies on the treatment of reconstructive and burn wounds showed that the elasticity of the regenerated skin was significantly better after 3-4 months with the combined use of MatriDerm and splitskin grafts, than if wounds were treated with split-skin grafts alone.

Elastin provide accelerated neoangiogenesis

Elastin is the key structural protein found in the extracellular matrix of all mammals  and exhibits multiple Biochemical and Mechanical effects.
Elastin acts as a matrix derived cytokine, positively influencing the proliferation of vessel forming cells. Endothelial cells start forming micro-tubes to connect the actively producing fibroblasts and their newly formed tissue with the blood circulation of the periphery. The collagen matrix guides and protects the newly-formed micro-vessels
Early signs of vascularisation appear after 3 days, full angiogenesis in 15 days.

 

Early vascularisation:

  • Ensures graft survival in a one-step procedure – even over exposed tendons, & bones
  • Supports fast healing
  • Secures stable wound closure
  • Reduces infection risk

 

Papers


Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615740/

2017 Sep 15;10(9). pii: E1086. doi: 10.3390/ma10091086.

Böhm S1, Strauß C2, Stoiber S3, Kasper C4,5, Charwat V6.

Abstract

Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process.


Reduced wound contraction and scar formation in punch biopsy wounds. Native collagen dermal substitutes. A clinical study.

http://www.ncbi.nlm.nih.gov/pubmed/7772472

Br J Dermatol. 1995 May;132(5):690-7.

De Vries HJ1, Zeegelaar JE, Middelkoop E, Gijsbers G, Van Marle J, Wildevuur CH, Westerhof W.

Abstract

In full-thickness skin wounds dermal regeneration usually fails, resulting in scar formation and wound contraction. We studied dermal regeneration by implantation of collagenous matrices in a human punch biopsy wound model. Matrices were made of native bovine collagen I fibres, and either hyaluronic acid, fibronectin, or elastin was added. Matrices were placed in 6-mm punch biopsy holes in seven patients (biopsies were used for the grafting of leg ulcers), and covered with a protective semi-permeable polyether urethane membrane. Histology, wound contraction and dermal architecture were studied. Dermal architecture was evaluated using a recently developed laser scatter technique. All collagen matrices showed a tendency to reduce wound contraction, compared with control wounds; elastin- and fibronectin-treated matrices showed significantly less contractionthan control wounds. Only the addition of elastin had a clear beneficial effect on dermal architecture; collagen bundles were more randomly organized, compared with control wounds, and wounds treated with collagen matrices coated with fibronectin or hyaluronic acid, or without coating. We conclude that the punch biopsy wound model provides important information on dermal regeneration in humans. Native collagen matrices with elastin contributed to dermal regeneration and reduced wound contraction, in contrast with matrices coated with fibronectin or hyaluronic acid, or without coating. Future clinical studies of large-area, full-thickness wounds will be required to establish their clinical relevance for leg ulcer and burn treatment.


Contracture of skin graft in human burns: effect of artificial dermis.

https://www.ncbi.nlm.nih.gov/pubmed/25270084

2014 Dec;40(8):1497-503. doi: 10.1016/j.burns.2014.08.007. Epub 2014 Sep 28.

Hur GY1, Seo DK1, Lee JW2.

Abstract

BACKGROUND:

Skin grafts with an artificial dermis have been widely used as a part of the efforts to minimize contractures and reduce donor-site scars. We conducted a prospective randomized clinical trial to study the effect of a dermal substitute by measuring the size of the graft after surgery for months.

METHOD:

The artificial dermis (Matriderm, Dr. Suwelack Skin and Health Care AG, Billerbeck, Germany) was applied in combination with a split-thickness autograft in 40 patients with acute burn wounds or scar reconstruction. Demographic and medical data were collected on each patient. We directly measured the graft size by using a transparent two-ply film (Visitrak Grid, Smith & Nephew Wound Management, Inc, Largo, FL, USA) intraoperatively and 1, 2, 3, and 6 months postoperatively. For effective data comparison, the size of the graft at the time of surgery was taken to be “100%.” Then, the size in each phase was estimated in percentage (%).

RESULT:

During the 1st month, the average size was 89%. The figure decreased to 86% and 82% in the 2nd and 3rd months, respectively. In the 6th month, it slightly rebounded to 85% but failed to return to the original state. The size of patients with acute burns was smaller than the size of scar patients as follows: 85-91% in the 2nd month, 81-87% in the 3rd month, and 85-96% in the 6th month.

CONCLUSION:

This study examined the progress of skin grafts through the measurement of graft size in the human body. The grafted skin underwent contracture and remodeling for 3-6 months. In terms of skin contraction, an acute burn was more serious than scar reconstruction. The use of an artificial dermis that contains elastin is very effective from the functional and esthetic perspective by minimizing contractures and enhancing skin elasticity.