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How the effect of SUPRATHEL® can be explained

References

1 Gladden 2008 “Current trends in lactate metabolism: introduction” Med. Sci. Sports Exerc. 40:475-476

2 Lu et al. 2002 “Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carciogenesis” J. Biol. Chem. 277:23111-5

3 Lu et al. 2005 “Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1” J. Biol. Chem. 280:41928-39

4 Constant et al. 2000 “Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia. “ Wound. Repair Regen. 8:353-360

5 Beckert et al. 2006 “Lactate stimulates endothelial cell migration.“ Wound. Repair Regen. 14: 321-324

6 Nareike et al. 2005 “Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappa transcriptional activities” Am. J. Physiol. Endocrinol. Metab. 289:E534-42

7 Milovanova et al. 2008 “Lactate stimulates vasculogenic stem cell via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1” Mol. Cell Biol. 28: 6248-61

8 Aslam et al. 2005 “High lactate in wounds may initiate vasculogeneis via stem cell homing“ J. Am. Coll. Surg. (3S):S58

9 Zieker et al. 2008 “Lactate modulates gene expression in human mesenchymal stem cells.” Langenbecks Arch. Surg 10Wagner et al. 2004 „Stimulation of fibroblast by lactate-mediated oxidants” Wound. Repair Regen. 12:368-73